Our Services

We offer a range of tissue processing and analysis services to augment our tissue procurement services. Each of these services is highly specialised so we welcome discussions about your specific needs.
Please call us on +44 (0)141 299 0055 or email enquiries@tissue-solutions.com

Antibody Cross—Reactivity Testing

We support therapeutic antibody development through cross—reactivity testing in human tissue and other species (GLP & non—GLP). Regulatory work is carried out using the FDA, EMEA, and MAFF panels of normal tissues.

Our experience means we can also support immunotoxicity lymphocyte sub—group analysis, cell proliferation studies, and diagnostic research services, as well as target validation and clinical biomarker assays.

Cellular DNA and RNA Extraction Service

Isolation of intact human genetic material is a vital step for many molecular biology applications. We offer simple, high yield extraction of gDNA, total RNA, mRNA and miRNA from human tissues. Samples are sourced for you by Tissue Solutions, and DNA/RNA is delivered to you in short turnaround times. Extractions can be performed on the following:

  • Tissue samples or biopsies
  • Blood and bio—fluids
  • Cells
  • FFPE samples
Histology and Immunohistochemistry (IHC)

We offer expert antibody and screening services in association with our collaborative partner, a specialist GLP accredited provider of IHC and contract histology services.

  • Proof of principle/mechanism studies
  • Antibody/target validation
  • Target distribution studies in normal and diseased tissues.
  • IHC/ISH expression in tissues or cell lines
Plucked Hair Labelling

We provide a highly sensitive gene expression profiling service (qRT-PCR) to help develop robust non—invasive biomarkers that measure drug—induced changes in gene expression at the mRNA level from individual hairs plucked from patients undergoing specific drug regimes. This biomarker technology has the potential to provide valuable insights for decision—making in drug development; it provides an early indication of toxicity, allowing you to measure the effect of drug exposure on targeted signalling pathways and evaluate dosage and scheduling. Importantly, this proprietary cDNA amplification and labelling technology preserves initial mRNA relative abundance.

Establishment and Characterisation of Primary Cell Lines

We can establish and culture new primary cell lines derived from fresh human tissue, which opens up a wide range of possibilities in terms of the types of cell line we can provide using clinically relevant material:
We can provide cell lines:

  • Established from both normal and diseased tissues e.g. cancers, COPD, RA, etc ;
  • From single or multiple donors,
  • With detailed clinical information relevant to that cell line.

Our extensive knowledge of primary cell culturing has led to the development and validation of specialised media formulations, significantly improving both the establishment process and the performance of the cells. We are also happy to tackle the isolation of so—called “difficult” cells.

Pancreatic Islet Studies

If you commonly outsource studies involving human pancreatic islets for the study of metabolic disorders or evaluating new drugs then we can help on a contract service basis. Batches of pancreatic islets are isolated from normal human donors, and we guarantee their quality and viability. They can be used in the study of:

  • Insulin production
  • Cell metabolism
  • Immunosuppression
  • Metabolic Disorders
Patient—Derived Tumour Xenograft Models

PDX cancer models provide an array of opportunities for translational research, allowing a more relevant evaluation of targeted therapies and better predictions of clinical outcome.
Currently available models include:

  • Colorectal cancer
  • Breast cancer (various hormone subtypes)
  • Prostate cancer
  • Bladder cancer
  • Lung cancer

Each of these services is highly specialised so we would welcome discussions with you about your specific needs.

 

For more information please contact us:

Email: enquiries@tissue-solutions.com
Tel: +44 (0)141 299 0055 Fax: +44 (0)141 299 0054